Green synthesis of iron oxide nanoparticles using Euphorbia hirta leaf extract: Characterization, anti-cancer and antimicrobial activity
Green synthesis of iron oxide nanoparticles using Euphorbia hirta leaf extract: Characterization, anti-cancer and antimicrobial activity
G. Venkatesh,Khayala Mammadova,3 Authors,P. Vennila
TLDR
Iron oxide nanoparticles synthesized using Euphorbia hirta leaf extracts were characterized using FTIR, UV-Vis, X-ray diffraction, SEM, and HR-transmission electron microscopy methods and exhibited a high degree of toxicity towards the MCF-7 cell line.
Abstract
Recent advancements in green synthesis processes suggest that nanoparticles produced from plant extracts are less toxic and more effective, and such particles are currently being used in a variety of medical applications. Iron oxide nanoparticles (FeONPs) were synthesized using Euphorbia hirta leaf extracts and characterized using FTIR, UV-Vis, X-ray diffraction, SEM, and HR-transmission electron microscopy methods. The EH-FeONPs were screened for their cytotoxic activity using the MTT assay. In vitro, the synthesized EH-FeONPs exhibited a high degree of toxicity towards the MCF-7 cell line. Antimicrobial studies were conducted to evaluate the efficacy of the fabricated EH-FeONPs against a variety of bacterial and fungal pathogens. Quantum chemical calculations were performed for Euphorbia hirta macromolecules such as luteolin, kaempferol, rutin, myricitrin, luteolin 7-O-glucoside, quercitrin, ellagic acid, chlorogenic acid, and their Fe₂O₂ nanocage macromolecules.
KEY WORDS: Euphorbia hirta, Iron oxide nanoparticles, Cytotoxicity, Antimicrobial, DockingBull. Chem. Soc. Ethiop. 2025, 39(12), 2509-2522DOI: https://dx.doi.org/10.4314/bcse.v39i12.11