Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
Laura M. Richards,Owen Whitley,34 Authors,Trevor J Pugh
2021 · DOI: 10.1038/s43018-020-00154-9
Nature Cancer · 204 Citations
TLDR
It is proposed that glioblastomas grow out of a fundamental GSC-based neural wound response transcriptional program, which is a promising target for new therapy development.