Genes and proteins of the alternative steroid backdoor pathway for dihydrotestosterone synthesis are expressed in the human ovary and seem enhanced in the polycystic ovary syndrome.
Genes and proteins of the alternative steroid backdoor pathway for dihydrotestosterone synthesis are expressed in the human ovary and seem enhanced in the polycystic ovary syndrome.
N. Marti,J. Galván,5 Authors,C. Flück
2017 · DOI: 10.1016/j.mce.2016.07.029
Molecular and Cellular Endocrinology · 63 Citations
TLDR
Immunohistochemical studies showed specific localization of aldo-keto reductases, 5α-reductases and retinol dehydrogenase expressed in the human ovary, indicating that the ovary might produce dihydrotestosterone via the backdoor pathway.