General anesthesia and the cortical stranglehold on consciousness.
General anesthesia and the cortical stranglehold on consciousness.
D. Pal,G. Mashour
2022 · DOI: 10.1016/j.neuron.2022.05.014
Neuron · 8 Citations
TLDR
It is demonstrated that diverse general anesthetic regimens all reversibly and selectively synchronize spontaneous activity of pyramidal neurons in layer 5 of mouse cortex, which has implications for the mechanism of consciousness and anesthetic-induced unconsciousness.
Abstract
In this issue of Neuron, Bharioke et al. (2022) demonstrate that diverse general anesthetic regimens all reversibly and selectively synchronize spontaneous activity of pyramidal neurons in layer 5 of mouse cortex. We discuss the implications of these findings for the mechanism of consciousness and anesthetic-induced unconsciousness.