Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke: implications for COPD and lung cancer.
Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke: implications for COPD and lung cancer.
I. Sundar,I. Rahman
2016 · DOI: 10.1152/ajplung.00253.2016
58 Citations
TLDR
CS-induced genotoxic stress differentially affects the expression of epigenetic modulators that regulate transcription of target genes via DNA methylation and site-specific histone modifications, which may have implications in devising epigenetic-based therapies for COPD and lung cancer.