Folic Acid and Folinic Acid for Reducing Side Effects in Patients Receiving Methotrexate for Rheumatoid Arthritis
Folic Acid and Folinic Acid for Reducing Side Effects in Patients Receiving Methotrexate for Rheumatoid Arthritis
B. Shea,Michael V. Swinden,6 Authors,P. Tugwell
2014 · DOI: 10.3899/jrheum.130738
Journal of Rheumatology · 425 Citations
TLDR
A protective effect of supplementation with either folic or folinic acid for patients with RA during treatment with MTX is supported, with a clinically important significant reduction shown in the incidence of GI side effects and hepatic dysfunction.