Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
Blaine N. Armbruster,Xiang Li,2 Authors,B. Roth
2007 · DOI: 10.1073/pnas.0700293104
Proceedings of the National Academy of Sciences of the United States of America · 1,901 Citations
TLDR
A facile approach for designing families of GPCRs with engineered ligand specificities will prove to be powerful tools for selectively modulating signal-transduction pathways in vitro and in vivo.