Enteric Salmonella Infection Inhibits Paneth Cell Antimicrobial Peptide Expression
Enteric Salmonella Infection Inhibits Paneth Cell Antimicrobial Peptide Expression
N. Salzman,M. Chou,3 Authors,Y. Paterson
2003 · DOI: 10.1128/IAI.71.3.1109-1115.2003
Infection and Immunity · 154 Citations
TLDR
It is found that oral inoculation of mice with wild-type Salmonella enterica serovar Typhimurium decreases the expression of α-defensins (called cryptdins in mice) and lysozyme, a type of microbicidal molecule that is important in mucosal host defense against invasion by enteric pathogens.