Enantioselective iridium-catalyzed carbonyl allylation from the alcohol or aldehyde oxidation level via transfer hydrogenative coupling of allyl acetate: departure from chirally modified allyl metal reagents in carbonyl addition.
Enantioselective iridium-catalyzed carbonyl allylation from the alcohol or aldehyde oxidation level via transfer hydrogenative coupling of allyl acetate: departure from chirally modified allyl metal reagents in carbonyl addition.
I. Kim,Ming‐Yu Ngai,M. Krische
2008 · DOI: 10.1021/ja805722e
Journal of the American Chemical Society · 222 Citations
TLDR
This protocol for asymmetric carbonyl allylation transcends the barriers imposed by oxidation level and the use of preformed allyl metal reagents and isopropanol, a secondary alcohol, may serve as terminal reductant.