Enantioselective Allylic C-H Oxidation of Terminal Olefins to Isochromans by Palladium(II)/Chiral Sulfoxide Catalysis.
Enantioselective Allylic C-H Oxidation of Terminal Olefins to Isochromans by Palladium(II)/Chiral Sulfoxide Catalysis.
Stephen E. Ammann,Wei Liu,M. White
2016 · DOI: 10.1002/anie.201603576
114 Citations
TLDR
The enantioselective synthesis of isochroman motifs has been accomplished by palladium(II)-catalyzed allylic C-H oxidation from terminal olefin precursors using a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand.