Efficient delivery of VEGF-A mRNA for promoting diabetic wound healing via ionizable lipid nanoparticles.
Efficient delivery of VEGF-A mRNA for promoting diabetic wound healing via ionizable lipid nanoparticles.
Wenhui Zha,Ji Wang,6 Authors,Xinsong Li
2022 · DOI: 10.1016/j.ijpharm.2022.122565
International journal of pharmaceutics · 43 Citations
TLDR
The LNP/VEGF-A mRNA nanoparticles can be taken up by cells to express protein effectively and improve diabetic wound healing, which might have potential application in the treatment of chronic diabetic wounds as a protein replacement therapy.