Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration.
Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration.
Masao Kamimura,M. Sugawara,2 Authors,J. Nakanishi
TLDR
A method was developed for photocontrolling cell adhesion on a gel substrate with defined mechanical properties that resulted in precise patterning of geometrically controlled cell clusters and their migration induction by spatiotemporally controlled photo-irradiation of the substrate.
Abstract
A method was developed for photocontrolling cell adhesion on a gel substrate with defined mechanical properties. Precise patterning of geometrically controlled cell clusters and their migration induction became possible by spatiotemporally controlled photo-irradiation of the substrate. The clusters exhibited unique collective motion that depended on substrate stiffness and cluster geometry.