Disulphide trapping of the GABAA receptor reveals the importance of the coupling interface in the action of benzodiazepines
Disulphide trapping of the GABAA receptor reveals the importance of the coupling interface in the action of benzodiazepines
S. Hanson,C. Czajkowski
2011 · DOI: 10.1111/j.1476-5381.2010.01073.x
British Journal of Pharmacology · 13 Citations
TLDR
Although the functional effects of benzodiazepines on GABAA receptors have been well characterized, the structural mechanism by which these modulators alter activation of the receptor by GABA is still undefined.