Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly
Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly
Kexin Kang,Qiaoni Shi,Xu Wang,Ye-guang Chen
2022 · DOI: 10.1083/jcb.202205069
Journal of Cell Biology · 33 Citations
TLDR
Dvl2 phase separation plays a crucial role in assembly of the Wnt receptor signalosome and disruption of the β-catenin destruction complex.
Abstract
Kang et al. demonstrate that Dvl2 undergoes phase separation and displays a rapid accumulation to the plasma membrane upon Wnt stimulation. Dvl2 phase separation plays a crucial role in assembly of the Wnt receptor signalosome and disruption of the β-catenin destruction complex.