Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents.
Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents.
Haijun Chen,Zhengduo Yang,6 Authors,Jia Zhou
2013 · DOI: 10.1021/ML3003082
ACS Medicinal Chemistry Letters · 111 Citations
TLDR
Compound 11 (HJC0152) has been demonstrated to significantly suppress MDA-MB-231 xenograft tumor growth in vivo, indicating its great potential as efficacious and orally bioavailable therapeutics for human cancer.