Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport.
Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport.
A. J. Lambert,Julie A. Buckingham,Helen M Boysen,M. Brand
2008 · DOI: 10.1016/j.bbabio.2008.03.005
Biochimica et Biophysica Acta · 117 Citations
TLDR
It is concluded that DPI has the novel and potentially very useful ability to prevent superoxide production from the site in complex I that is active during reverse electron transport, without affectingsuperoxide production during forward electron transport.