Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
E. Sahai,C. Marshall
2003 · DOI: 10.1038/ncb1019
Nature Cell Biology · 1,212 Citations
TLDR
Two modes of tumour-cell motility in 3D matrices that involve different usage of Rho signalling are identified and combined blockade of extracellular proteases and ROCK negates the ability of tumours to switch between modes of motility and synergises to prevent tumour cell invasion.