Differentiation of Bone Marrow Mesenchymal Stem Cells into the Smooth Muscle Lineage by Blocking ERK/MAPK Signaling Pathway

In conclusion, BMMSCs treated with MEK inhibitor gain a SMC-like phenotype with ligand-induced cell contractility to endothelin in vitro, which has obvious implications for cell therapeutics and tissue engineering of hollow visceral organs such as blood vessels.