Different Residues in the GABAA Receptor Benzodiazepine Binding Pocket Mediate Benzodiazepine Efficacy and Binding

The effects of individually mutating 22 residues throughout the BZD binding pocket on the abilities of eszopiclone, zolpidem, and flurazepam to potentiate IGABA are measured, indicating that the structural mechanisms underlying the ability of BzD ligands with divergent structures to potentiation of I GABA are distinct.