Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine.
Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine.
A. Haghikia,Stefanie Jörg,19 Authors,R. Linker
2015 · DOI: 10.1016/j.immuni.2015.09.007
Immunity · 608 Citations
TLDR
Dietary long-chain fatty acids enhanced differentiation and proliferation of T helper 1 and/or Th17 cells and impaired their intestinal sequestration via p38-MAPK pathway and dietary short-chain FAs expanded gut T regulatory (Treg) cells by suppression of the JNK1 and p38 pathway.