Detection, characterization, and screening of heme-binding molecules by mass spectrometry for malaria drug discovery.
Detection, characterization, and screening of heme-binding molecules by mass spectrometry for malaria drug discovery.
Katalina Muñoz-Durango,A. Maciuk,7 Authors,B. Figadère
2012 · DOI: 10.1021/ac300065t
Analytical Chemistry · 24 Citations
TLDR
The described method detects heme-binding compounds by mass spectrometry, using dissociation of the drug-heme adducts to evaluate putative antiplasmodial activity and is an efficient early stage screening for complex mixtures like natural extracts.