Design of multi-target peptide modulators for protein chaperone networks.
Design of multi-target peptide modulators for protein chaperone networks.
Luca Torielli,Matteo Castelli,25 Authors,Giorgio Colombo
2025 · DOI: 10.1016/j.str.2025.07.021
Structure · 2 Citations
TLDR
Peptide Cdk4-2 is shown to simultaneously bind Hsp70, Hsp90, and co-chaperone Cdc37, and is a promising lead for therapeutic development, expanding the molecular space of modulators of cancer-associated multiprotein machineries.