Derivation and Validation of a Score for Predicting Poor Neurocognitive Outcomes in Acute Carbon Monoxide Poisoning

Key Points Question Can a novel clinical scoring system predict poor neurocognitive outcomes after acute carbon monoxide poisoning? Findings This prognostic study developed and externally validated a prediction model including 5 risk factors associated with poor neurocognitive outcome at 1 month, creatine kinase level, hyperbaric oxygen therapy, Glasgow Coma Scale score, age, and shock (COGAS score), among patients with carbon monoxide poisoning. COGAS score showed excellent discrimination performance. Meaning These findings suggest that use of a reliable prediction model during the early phase of carbon monoxide poisoning could help identify patients at risk of poor neurocognitive sequelae.