Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella.
Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella.
Fabian Rivera-Chávez,Lillian F. Zhang,8 Authors,A. Bäumler
2016 · DOI: 10.1016/j.chom.2016.03.004
Cell Host and Microbe · 727 Citations
TLDR
Salmonella virulence factors and antibiotic treatment promote pathogen expansion through the same mechanism: depletion of butyrate-producing Clostridia to elevate epithelial oxygenation, allowing aerobic Salmonella growth.