Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts.
Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts.
C. Altar,L. Jurata,9 Authors,J. Brockman
2005 · DOI: 10.1016/J.BIOPSYCH.2005.03.031
Biological Psychiatry · 304 Citations
TLDR
Decreases in hippocampal neuron gene expression are consistent with brain imaging and microarray studies of the frontal cortex in schizophrenia, suggesting a mitochondrial and ubiquitin-proteasome hypofunctioning of dentate granule neurons may contribute to the deficits of schizophrenia.