UPDF AI

Deep generative design of RNA family sequences

Shunsuke Sumi,Michiaki Hamada,Hirohide Saito

2024 · DOI: 10.1038/s41592-023-02148-8
Nature Methods · 59 Citations

TLDR

RNA family sequence generator (RfamGen) is a deep generative model that designs RNA family sequences in a data-efficient manner by explicitly incorporating alignment and consensus secondary structure information and significantly improves the ability to design functional RNA.