Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system.

This review introduces the PDE families whose members are expressed in cells of the cardiovascular system including cardiomyocytes, vascular smooth muscle cells, and vascular endothelial cells and attempts to emphasize how changes in the activity, expression, and targeting of PDE influence cyclic nucleotide-mediated regulation of the behavior of these cells.