Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation
L. Sauguet,A. Shahsavar,7 Authors,M. Delarue
2013 · DOI: 10.1073/pnas.1314997111
Proceedings of the National Academy of Sciences of the United States of America · 204 Citations
TLDR
The large structural variability in the neutral pH structure observed in the four copies of the pentamer present in the asymmetric unit has been used to analyze the intrinsic fluctuations in this state, which are found to prefigure the transition to the open state.