Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine
Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine
Pauline Andreu,S. Colnot,8 Authors,B. Romagnolo
2005 · DOI: 10.1242/dev.01700
Development · 324 Citations
TLDR
It is shown that Apc is a crucial determinant of cell fate in the murine intestinal epithelium, and perturbs differentiation along the enterocyte, goblet and enteroendocrine lineages, and promotes commitment to the Paneth cell lineage through β-catenin/Tcf4-mediated transcriptional control of specific markers of Paneth cells, the cryptdin/defensin genes.