Critical Role of Water Molecules in Proton Translocation by the Membrane-Bound Transhydrogenase.
Critical Role of Water Molecules in Proton Translocation by the Membrane-Bound Transhydrogenase.
P. Padayatti,J. Leung,9 Authors,Qinghai Zhang
2017 · DOI: 10.1016/j.str.2017.05.022
Structure · 11 Citations
TLDR
It is shown that transient water flows across a narrow pore and a hydrophobic "dry" region in the middle of the membrane channel, with key residues His42α2 and Thr214β displaying a conformational change, respectively, to gate the channel access to both cytoplasmic and periplasmic chambers, providing new insights into the gating mechanism of proton translocation in TH.