Confinement and low adhesion induce fast amoeboid migration of slow mesenchymal cells.
Confinement and low adhesion induce fast amoeboid migration of slow mesenchymal cells.
Yan-Jun Liu,M. Le Berre,6 Authors,M. Piel
2015 · DOI: 10.1016/j.cell.2015.01.007
Cell · 805 Citations
TLDR
It is reported that, in the absence of focal adhesions and under conditions of confinement, mesenchymal cells can spontaneously switch to a fast amoeboid migration phenotype and, Interestingly, transformed cells are more prone to adopt this fast migration mode.