Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.
Xiaohui Yan,Zhongyi Hu,27 Authors,Lin Zhang
2015 · DOI: 10.1016/j.ccell.2015.09.006
Cancer Cell · 600 Citations
TLDR
A comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas suggests that the expression and dysregulation of lNCRNAs are highly cancer type specific compared with protein-coding genes.