Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.
Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.
J. Shern,Li Chen,24 Authors,Javed Khan
2014 · DOI: 10.1158/2159-8290.CD-13-0639
Cancer Discovery · 648 Citations
TLDR
This is the most comprehensive genomic analysis of rhabdomyosarcoma to date, finding multiple genes were recurrently altered, including NRAS, KRAS, HRAS, FGFR4, PIK3CA, CTNNB1, FBXW7, and BCOR.