Chitosan drug binding by ionic interaction.
Chitosan drug binding by ionic interaction.
Yaowalak Boonsongrit,A. Mitrevej,B. W. Mueller
2006 · DOI: 10.1016/J.EJPB.2005.09.002
European journal of pharmaceutics and biopharmaceutics · 166 Citations
TLDR
The ionic interaction between drug and chitosan is low and too weak to control the drug release and the high burst release of drugs from chitOSan micro/nanoparticles was observed regardless of the pH of dissolution media.