Cellular response to substrate rigidity is governed by either stress or strain.
Cellular response to substrate rigidity is governed by either stress or strain.
A. K. Yip,Katsuhiko Iwasaki,6 Authors,Y. Sawada
2013 · DOI: 10.1016/j.bpj.2012.11.3805
Biophysical Journal · 122 Citations
TLDR
Traction stress measurements carried out using fibroblasts on polyacrylamide gels with Young's moduli suggest sustained substrate strain on soft substrates and sustained traction stress on stiff substrates may be factors governing cellular responses to substrate rigidity.