Cellular actions of the insulin-like growth factor binding proteins.
Cellular actions of the insulin-like growth factor binding proteins.
S. Firth,R. Baxter
2002 · DOI: 10.1210/ER.2001-0033
Endocrine reviews · 1,872 Citations
TLDR
In addition to their roles in IGF transport, the six IGF-binding proteins (IGFBPs) regulate cell activity in various ways and manipulation of IGFBP-regulated pathways is speculated to offer therapeutic opportunities in cancer and other diseases.