Cell locomotion and focal adhesions are regulated by substrate flexibility.
Cell locomotion and focal adhesions are regulated by substrate flexibility.
R. Pelham,Yu-li Wang
1997 · DOI: 10.1073/PNAS.94.25.13661
Proceedings of the National Academy of Sciences of the United States of America · 3,114 Citations
TLDR
The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.