Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Inki Kim,W. Xu,John Calvin Reed
2008 · DOI: 10.1038/nrd2755
Nature reviews. Drug discovery · 1,814 Citations
TLDR
The accumulation of unfolded proteins in the endoplasmic reticulum represents a cellular stress induced by multiple stimuli and pathological conditions, which triggers an evolutionarily conserved series of signal-transduction events, which constitutes the unfolded protein response.