Caution!! Reappearance of remimazolam effect after a flumazenil bolus: a larger bolus of flumazenil and a lower total remimazolam clearance are higher risks

The difference between the two antagonists is explained to understand the mechanisms of action and the time courses of the reversal effect are different between flumazenil and sugammadex, and risks of reappearance of remimazolam effect after a flumAZenil bolus against residual remimzolam using pharmacokinetic simulations are considered.