Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models
Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models
K. Kwon,A. Barve,2 Authors,A. Kong
2007 · DOI: 10.1111/j.1745-7254.2007.00694.x
Acta Pharmacologica Sinica · 158 Citations
TLDR
The cellular signaling cascades mediated by Nrf2, NF-κB, AP-1, MAPKs and COX-2 are discussed, which have been considered to play pivotal roles in tumor initiation, promotion and progression processes, and could be promising molecular targets for the design of drugs targeting cancer prevention and therapy.