Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity
Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity
H. Christianson,Katrin J. Svensson,2 Authors,M. Belting
2013 · DOI: 10.1073/pnas.1304266110
Proceedings of the National Academy of Sciences of the United States of America · 800 Citations
TLDR
It is concluded that cancer cell-derived exosomes use heparan sulfate proteoglycans (HSPGs) for their internalization and functional activity, which significantly extends the emerging role of HSPGs as key receptors of macromolecular cargo.