c-Myc transactivation of LDH-A: implications for tumor metabolism and growth.
c-Myc transactivation of LDH-A: implications for tumor metabolism and growth.
H. Shim,C. Dolde,5 Authors,C. Dang
1997 · DOI: 10.1073/PNAS.94.13.6658
Proceedings of the National Academy of Sciences of the United States of America · 1,123 Citations
TLDR
It is suggested that an increased LDH-A level is required for the growth of a transformed spheroid cell mass, which has a hypoxic internal microenvironment and is necessary for c-Myc-mediated transformation.