Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery.
Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery.
L. Ardouin,H. Luche,20 Authors,B. Malissen
2016 · DOI: 10.1016/j.immuni.2016.07.019
Immunity · 193 Citations
TLDR
It is shown that thymic XCR1(+) DCs undergo a high rate of maturation, accompanied by profound gene-expression changes that are essential for central tolerance and also happen in germ-free mice, arguing against the commonly held view that tolerogenicDCs undergo incomplete maturation.