Block of GABA(A) receptor ion channel by penicillin: electrophysiological and modeling insights toward the mechanism.
Block of GABA(A) receptor ion channel by penicillin: electrophysiological and modeling insights toward the mechanism.
A. Rossokhin,I. Sharonova,2 Authors,V. Skrebitsky
2014 · DOI: 10.1016/j.mcn.2014.10.001
34 Citations
TLDR
The predicted structural models support the described mechanism of PNG block, and it is shown that PNG binds close to the intracellular vestibule, similar to other GABA(A)R antagonists.