Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.
Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.
J. Gould,L. S. Leonard,6 Authors,K. Gaido
1998 · DOI: 10.1016/S0303-7207(98)00084-7
Molecular and Cellular Endocrinology · 512 Citations
TLDR
It is demonstrated that BPA is not merely a weak estrogen mimic but exhibits a distinct mechanism of action at the ERalpha, which is significantly less potent than E2 in activating ER-WT.