Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo.
Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo.
Yan Pan,Ying-jian Li,5 Authors,F. Cui
2002 · DOI: 10.1016/S0378-5173(02)00486-6
International journal of pharmaceutics · 676 Citations
TLDR
CS-NPs enhanced the intestinal absorption of insulin to a greater extent than the aqueous solution of CS in vivo, and showed a great initial burst with a pH-sensitivity property.