Bio-bar-code-based DNA detection with PCR-like sensitivity.
Bio-bar-code-based DNA detection with PCR-like sensitivity.
J. Nam,S. Stoeva,C. Mirkin
2004 · DOI: 10.1021/JA049384+
Journal of the American Chemical Society · 703 Citations
TLDR
Novel two-component oligonucleotide-modified nanoparticle probes have been designed and used in a bio-bar-code assay with a 500 zeptomolar target DNA sensitivity limit.