Bilirubin and glutathione have complementary antioxidant and cytoprotective roles
Bilirubin and glutathione have complementary antioxidant and cytoprotective roles
T. Sedlak,Masoumeh Saleh,3 Authors,S. Snyder
2009 · DOI: 10.1073/pnas.0813132106
Proceedings of the National Academy of Sciences of the United States of America · 503 Citations
TLDR
It is shown that the water-soluble GSH primarily protects water soluble proteins, whereas the lipophilic bilirubin protects lipids from oxidation, and that RNA interference depletion of BVR increases oxidation of lipids more than protein.