beta(3)-Adrenoceptor agonists: potential, pitfalls and progress.

Beta(3)-adrenoceptor agonists have a more rapid insulin-sensitising than anti-obesity effect, possibly because stimulation of lipid oxidation rapidly lowers intracellular long-chain fatty acyl CoA and diacylglycerol levels, which may deactivate those protein kinase C isoenzymes that inhibit insulin signalling.