BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure
BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure
Qiming Duan,Sarah McMahon,12 Authors,Saptarsi M. Haldar
2017 · DOI: 10.1126/scitranslmed.aah5084
Science Translational Medicine · 225 Citations
TLDR
It is demonstrated that treatment with the BET bromodomain inhibitor JQ1 has therapeutic effects during severe, preestablished HF from prolonged pressure overload, as well as after a massive anterior myocardial infarction in mice.